Midway via his occupation, Cees Dekker reinvented himself. Right after decades of hardcore physics, he shifted his emphasis to ‘nanobiology’ at the turn of your millennium. A phrase he coined himself, to be a make a difference of point.
Our group scientific studies bacterial cell division and is particularly aiming to represent a ‘bottom up biology’ in synthetic cells which can autonomously divide. Our key fascination lies in cell division, chromatin composition, and spatial Management.
[Laughs] ‘It had been absolutely an incredible hazard! At some time, I used to be very well informed that it could go Erroneous Which I could turn into a lot less prosperous, but I just dismissed that. Curiosity has constantly been my strongest driving power. And fortuitously it all labored out.’
Because 2000, Dekker has shifted the leading target of his get the job done in the direction of biophysics the place he studies the Qualities of solitary biomolecules and cells utilizing the tools of nanotechnology. This variation of subject was pushed by his fascination for your impressive operating of Organic molecular structures, along with with the extensive-term point of view a large number of interesting discoveries may be envisioned in this area.[5] Existing traces of exploration in his biophysics team are during the parts of:[six]
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and initially ever analyze on the dynamics DNA supercoils and the discovery of supercoil hopping
Experimental stage diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
All parameters ceesdekker had been the exact same for every panel in this video, except for the Preliminary placement on the 6hb rod (revealed in blue) over the nanopore. Simulations that terminated early because of translocation in the rod throughout the pore are marked by a gray qualifications.
Instance (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in grey, the rim with the pore is highlighted in crimson, in addition to a 3D rendering on the movement in the DNA rod is exhibited.
The rotors harness energy from the nanoscale drinking water and ion movement that's created by a static chemical or electrochemical probable gradient inside the nanopore, which can be established via a salt gradient or applied voltage, respectively. These synthetic nanoengines self-Arrange and operate autonomously in physiological disorders, suggesting strategies to constructing Electrical power-transducing motors at nanoscale interfaces.
But carbon nanotubes have remained a investigation matter of significant curiosity to several. Without a doubt, the outlook on making use of carbon nanotubes to construct sensible devices, in areas such as radio-frequency electronics, electronic electronics and versatile electronics, stays vibrant.
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division
2006, 1st demonstration of molecular sorting in a lab on the chip employing biomotors; discovery of nanobubbles in good-state nanopores; and very first estimate of electrokinetic Electrical power conversion inside a nanofluidic channel
Let’s first search back again at this time whenever you chose to shift your emphasis from superconductivity and nanotubes to biology at the conclusion of the nineteen nineties.
2013, managed shaping of Stay bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes